Abstract: The Integrated Traditional Chinese and Western Medicine School has a Confucian background. In terms of the view of truth, the doctors of the School were influenced by the monism of Cheng-Zhu Neo-Confucianism and held the monism of truth in medicine. The monism of truth made the doctors of the School believe that there is a possibility of integration between Chinese and Western medicine, which became the metaphysical basis of their integration of Chinese and Western medicine. In terms of cosmology, the doctors of the School adhered to the universe generation model of Tai-Chi's Qi Transformation in the Book of Changes, emphasized the world and body of Qi, and criticized the theological creationism in Western medicine books. In terms of the view of medicine and the Book of Changes, the doctors of the School emphasized the connection between medicine and the Book of Changes, explained medical principles with principles in the Book of Changes, or applied the thinking mode of the Book of Changes to clinical practice and expounded new ideas for drugs. In terms of values, the doctors of the School believed that medicine was a benevolent art to save the world and save lives, and pursued Confucianism as a value. With the spread of scientific culture and the emergence of scientific Chinese medicine, the Chinese medicine community began to pay attention to the exploration of medical principles in the physical world, and the Confucian background of the doctors of the School gradually faded.