Abstract: A study was conducted on the issue about estimating the creativity of inventions of Chinese medicine compositions and the relationship between the creativity of inventions of Chinese medicine compositions and the pharmacology of Chinese medicine. It is argued that if the invention of Chinese medicine composition can be obtained by technicians in the related field only according to the existing prescriptions by logical analysis, reasoning or limited experiments based on the known pharmacology of Chinese medicine without any unexpected technical effect, then the invention of the Chinese medicine composition is not creative. However, if the raw materials or technical effect of the Chinese medicine composition is not easy to think of, the invention of the Chinese medicine composition is creative. On the relationship between creativity and pharmacology of Chinese medicine, creative inventions must be in line with the pharmacology of Chinese medicine, but inventions conform to the pharmacology of Chinese medicine are not necessarily creative. Besides, people's understanding of the pharmacology of Chinese medicine is constantly expanding and deepening.