Abstract: Animation technology provides a new pathway for the communication of Chinese medicine culture, but the current situation of Chinese medicine animation is not satisfactory. Based on the analysis of the "5W" communication model, it is found that the talent gap, the lack of communication content, the inadequate use of communication channels, the narrow scope of audience, and the poor feedback of communication information led to the difficulties in the communication of Chinese medicine animation. Thus, it is suggested that to cultivate composite talents of Chinese medicine animation, to improve the quantity and quality of Chinese medicine animation by multi-lateral cooperation, to enrich and innovate Chinese medicine animation contents, to open up multiple communication channels online and offline, as well as to transform and upgrade to meet the needs of different audiences are the strategies to solve the difficulties of Chinese medicine animation.