Abstract: Strong ideological and political leadership is the core of implementing the fundamental task of cultivating virtue and nurturing talents, and the fundamental guarantee for cultivating new people to shoulder the great responsibility of national rejuvenation in the era. The "Great Ideological and Political Course" provides a rich practical field for ideological and political leadership, and is an important way and practical carrier to enhance ideological and political leadership. From this perspective, to promote the construction of "Great Ideological and Political Course" in universities, it is necessary to focus on the "big picture of the country", explore the strategic positioning of "Great Ideological and Political Course", and focus on cultivating socialist builders and successors, people with comprehensive development in morality, intelligence, physical fitness, aesthetics, and labor, and new generations who can shoulder the great responsibility of national rejuvenation; grasp the essence of the "great course", explore the core essence of the "Great Ideological and Political Course", clarify that the essence of the "Great Ideological and Political Course" is the ideological and political course, the key is to combine with reality, and the characteristic is "great", implementing the "big picture of the situation", exploring the implementation path of the "Great Ideological and Political Course", adhering to systematic thinking, and building a new pattern of education in building master talents, expanding big classrooms, and promoting big collaboration.