Abstract: Modern science and technology have provided paradigm shifts and technical support for the innovation of traditional Chinese medicine knowledge, achieving positive results. However, they also face challenges such as the lack of core thinking in traditional Chinese medicine, limitations in the construction of independent knowledge systems in traditional Chinese medicine, and the lack of humanistic values in traditional Chinese medicine. Philosophy and social sciences have irreplaceable value in assisting the interpretation of the connotation of traditional Chinese medicine knowledge, eliminating disciplinary barriers between different knowledge systems, and promoting cross-cultural dissemination of traditional Chinese medicine knowledge from the dimensions of knowledge attributes, knowledge construction, and knowledge dissemination. To this end, by strengthening the interpretation of knowledge content, we can strengthen our confidence in the development path of traditional Chinese medicine; deepen interdisciplinary integration and construct an independent knowledge system for traditional Chinese medicine; promote the construction of a discourse system, highlight the humanistic and medical value of traditional Chinese medicine, fully demonstrate the practical value of philosophy and social sciences in enhancing the understanding, communication, and dissemination of traditional Chinese medicine knowledge, and actively promote the joint efforts of philosophy and social sciences and natural sciences to promote the innovation of traditional Chinese medicine knowledge.